Doctor jumping out of his chair next to a large flaming heart

ACT FAST

Because this is where 
ATTR-CM is Headed

If your patient is experiencing HFpEF or other heart disease symptoms, ATTR-CM could be an underlying cause.1,2 ATTR-CM is a progressive, debilitating, and fatal disease with a median survival of 2.6 to 5.8 years following diagnosis for untreated patients.3-7 Early detection and identification are critical to slow disease progression.2,8

Recognize red-flag symptoms

use tests to help 
raise clinical suspicion

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diagnostic algorithm

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Defining ATTR Arrow right

Arrow right

ATTR-CM=cardiomyopathy of transthyretin-mediated amyloidosis; HFpEF=heart failure with preserved ejection fraction.

References:

  1. Maurer MS et al. J Am Coll Cardiol. 2016;68(2):161-172.
  2. Kittleson MM et al. J Am Coll Cardiol. 2023;81(11):1076-1126.
  3. Hawkins PN et al. Ann Med. 2015;47(8):625–638.
  4. aus dem Siepen F et al. Clin Res Cardiol. 2018;107(2):158-169.
  5. Gertz MA et al. Mayo Clin Proc. 1992;67(5):428-440.
  6. Swiecicki PL et al. Amyloid. 2015;22(2):123-131.
  7. Givens RC et al. Aging Health. 2013;9(2):229-235.
  8. Kittleson MM et al. Circulation. 2020;142(1):e7-e22.